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Most side effects reported in clinical trials have been mild to moderate and may improve as the body adjusts during dose escalation

For example, treatment of murine macrophages with GLP-1RAs in vitro inhibits monocyte chemoattractant protein-1 gene expression and p65 as well as tumor necrosis factor (TNF)- expression

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In the crypts, multiple signaling pathways in the niche, including Wnt, BMP, Notch, EGF, and Eph/Ephrin play important roles in the regulation of self-renewal and differentiation of intestinal stem cells (ISCs) [19]